The 2025 Pan-African Artificial Intelligence and Smart Systems Conference (PA-AISS 2025) will be hosted by the Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, as a hybrid event. Authors may choose to present their papers in-person or virtually. Successful submissions will be peer-reviewed and published in Springer Lecture Notes of the Institute for Computer Sciences, Social Informatics, and Telecommunications Engineering (LNICST) book series.